Sonobird: Ultrasound for glioblastoma

Forskare i laboratorium. Sonobird kan hjälpa läkemedel att komma igenom blod-hjärnbarriären. — Sonobird aims to help medications cross the blood-brain barrier using ultrasound.

Sonobird is a phase three study investigating whether recurrent glioblastoma can be treated with the help of ultrasound.

Sonocloud is implanted at the tumor site. Photo: Carthera — Sonocloud is implanted at the tumor site. *Photo: Carthera*

The study uses a device called Sonocloud, which is implanted into the brain to more effectively deliver chemotherapy directly into the tumor.

The Sonobird study compares treatment with Sonocloud in combination with carboplatin to standard care, including lomustine or temozolomide, in patients who have experienced a first recurrence of glioblastoma and are scheduled for planned surgery.

Opens the blood-brain barrier

Sonocloud uses ultrasound technology and is specially developed to temporarily open the difficult-to-penetrate blood-brain barrier in the area around the tumor. The blood-brain barrier is located at the level of the blood vessel walls. It protects the brain from toxic or inflammatory molecules but also prevents most drugs injected into the bloodstream from entering the brain tissue where the tumor is located.